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KMID : 0355519920160010063
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Korean Journal of Oral Biology
1992 Volume.16 No. 1 p.63 ~ p.68
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In vivo in vitro release kinetics, cell cytotoxicity and cellular growth survival of local 30% Minocycline delivery
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Yoon Soo-Han
Lee Song-Heun
Kim Joong-Soo
Oh Seog-Bae
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Abstract
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Present study was performed to examine in vitro and in vivo release kinetics, cell cytotoxicity and cellular growth survival of local 30% Minocycline delivery The purpose of this study was to determine the possibility of clinical use of 30% Minocycline load polycaprolactone film(Mino-strip). The size of Mino-strip is 6.5mm×2.5mm×0.3mm, Mwt: 5.7mg).
In vitro releasing test, each film showed a large initial burst effect within first one and two hours and more than 84% of Minocycline was releasing test, each film showed a large burst effect within first two and three hours. A steady state
kinetics was observed for 8 days both in vivo and in vitro releasing test. In cytotoxicity test, there was no significant cytotoxic effect in Mino-strip to human gingival fibroblast. In cellular growth survival test, there was no significant cellular growth survival effect in Mino-strip to human gingival fibroblast.
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KEYWORD
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